Symbol
Name
ID

H2-DMa
histocompatibility 2, class II, locus DMa
MGI:95921

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

decreased T cell proliferation

abnormal positive T cell selection

decreased CD4-positive, alpha-beta T cell number

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T-helper 1 physiology

abnormal professional antigen presenting cell physiology

decreased susceptibility to type IV hypersensitivity reaction

abnormal antigen presentation

abnormal antigen presentation via MHC class II

abnormal level of surface class II molecules

defective assembly of class II molecules

decreased interferon-gamma secretion

decreased susceptibility to experimental autoimmune encephalomyelitis

increased susceptibility to bacterial infection

Availability

Mouse Genotype

H2-DMa^tm1Doi/H2-DMa^tm1Doi

H2-DMa^tm1Liz/H2-DMa^tm1Liz

H2-DMa^tm1Lkrl/H2-DMa^tm1Lkrl

H2-DMa^tm1Luc/H2-DMa^tm1Luc

H2-DMa^tm2Liz/H2-DMa^tm2Liz

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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